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Related Experiment Videos

Heart-lung-liver transplantation

C M Dennis1, K D McNeil, J Dunning

  • 1Transplant Unit Papworth Hospital, Cambridge, United Kingdom.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

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Combined heart-lung-liver transplantation is a feasible procedure for patients with advanced lung and liver disease. This approach offers satisfactory long-term outcomes for selected individuals, improving survival and quality of life.

Area of Science:

  • Cardiology
  • Hepatology
  • Pulmonology
  • Transplantation Surgery

Background:

  • Cystic fibrosis and primary biliary cirrhosis can lead to advanced pulmonary and hepatic disease.
  • Portal hypertension is a significant complication in cystic fibrosis patients with hepatic fibrosis or cirrhosis.
  • Plexogenic pulmonary hypertension necessitates advanced treatment strategies.

Purpose of the Study:

  • To evaluate the feasibility and outcomes of combined heart-lung-liver transplantation.
  • To assess the long-term survival and functional status of patients undergoing this complex procedure.
  • To determine the efficacy of concurrent transplantation in managing combined cardiopulmonary and hepatic failure.

Main Methods:

  • Retrospective case series of four patients undergoing combined heart-lung-liver transplantation.

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  • Inclusion criteria: advanced cystic fibrosis or primary biliary cirrhosis with pulmonary hypertension.
  • Assessment of post-transplant survival, pulmonary function, hepatic function, and New York Heart Association class.

    • Main Results:

    • Three of four patients survived long-term (20, 50, 100 months) post-transplantation.
    • Survivors demonstrated well-preserved pulmonary function (FEV1 49-110% predicted) and normal hepatic function.
    • One patient with cystic fibrosis died early (day 16) due to pneumonia.

    Conclusions:

    • Combined heart-lung-liver transplantation is a viable option for carefully selected patients with end-stage cardiopulmonary and hepatic disease.
    • The procedure can lead to satisfactory long-term survival and functional recovery.
    • This complex surgical approach addresses multiple organ system failure effectively.