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Activation of the lamin A gene during rat liver development
Q A Hamid1, S Fatima, S Thanumalayan
1Centre for Cellular and Molecular Biology, Hyderabad, India.
FEBS Letters
|August 26, 1996
Abstract:
We have studied the regulation of expression of the A-type lamins, which are constituents of the nuclear lamina. During rat liver development, high levels of lamin A and C mRNAs were observed in 15-day fetal liver but were barely detectable in the adult. The chromatin conformation of the lamin A gene was sensitive to DNase I in 15-day fetal liver but became mostly insensitive in the adult. Lamin A and C proteins could be detected in fetal liver and persisted in the adult. Our evidence suggests that the lamin A gene is actively transcribed early in liver differentiation and its activity declines considerably in adult liver.