Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein turnover during puberty in normal children

S A Arslanian1, S C Kalhan

  • 1Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital, University of Pittsburgh, Pennsylvania 15213, USA.

The American Journal of Physiology
|January 1, 1996
PubMed
Summary

Puberty reduces protein breakdown and oxidation, with decreased insulin sensitivity impacting protein metabolism. Increased insulin-like growth factor I (IGF-I) may contribute to lower protein degradation during this stage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of multi-nutrient insufficiency on markers of one carbon metabolism in young women: response to a methionine load.

European journal of clinical nutrition·2015
Same author

Gestational weight gain and the risk of offspring obesity at 10 and 16 years: a prospective cohort study in low-income women.

BJOG : an international journal of obstetrics and gynaecology·2015
Same author

Is gestational weight gain associated with offspring obesity at 36 months?

Pediatric obesity·2014
Same author

Prematurity and programming: contribution of neonatal Intensive Care Unit interventions.

Journal of developmental origins of health and disease·2014
Same author

Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition.

Journal of pediatric gastroenterology and nutrition·2009
Same author

Cardiorespiratory fitness and abdominal adiposity in youth.

European journal of clinical nutrition·2006

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Research
  • Protein Metabolism

Background:

  • Puberty is associated with insulin resistance.
  • The impact of pubertal insulin resistance on whole-body protein metabolism is not well understood.

Purpose of the Study:

  • To investigate the role of protein metabolism in pubertal insulin resistance.
  • To compare whole-body leucine kinetics between prepubertal and pubertal children.

Main Methods:

  • Utilized a primed constant infusion of [1-13C]leucine.
  • Employed a stepwise hyperinsulinemic euglycemic clamp with indirect calorimetry.
  • Measured leucine flux (LRa), oxidation (LOX), and nonoxidative disposal (NOXLD) in Tanner I (prepubertal) and Tanner II-IV (pubertal) children.

Related Experiment Videos

Main Results:

  • Baseline leucine flux and oxidation were lower in pubertal children (Tanner II-IV) compared to prepubertal children (Tanner I).
  • Nonoxidative disposal was similar between the groups at baseline.
  • Insulin's ability to suppress leucine flux was significantly reduced in pubertal children during the clamp.
  • Insulin-like growth factor I (IGF-I) levels showed inverse correlations with leucine kinetics.

Conclusions:

  • Protein degradation and oxidation decrease during puberty, while protein synthesis remains unchanged.
  • Insulin's inhibitory effect on proteolysis is diminished in pubertal children.
  • Elevated pubertal IGF-I levels may contribute to the observed decrease in protein degradation.