Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

All trans retinoic acid

S H Advani1

  • 1Dept of Medical Oncology, Tata Memorial Hospital, Bombay.

The Journal of the Association of Physicians of India
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

All-trans retinoic acid (ATRA) effectively treats acute promyelocytic leukemia (APL) by inducing remission and resolving coagulopathy. The PML/RAR-alpha fusion gene indicates ATRA sensitivity, highlighting its potential as a differentiation therapy model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus Guidelines for the Use of Cyclin-Dependent Kinase (CDK) 4/6 Inhibitors in the Management of Hormone Receptor Positive (HR+ve), Her2-ve Early Breast Cancer (EBC).

South Asian journal of cancer·2025
Same author

Musculoskeletal chronic graft versus host disease - A rare complication of allogeneic hematopoietic stem cell transplantation: A case report and review of its literature.

South Asian journal of cancer·2018
Same author

The Pattern of Malignant Lymphoma in India: A Study of 1371 Cases.

Leukemia & lymphoma·2016
Same author

Primary Liver Lymphoma: A Case Report with Review of Literature.

Leukemia & lymphoma·2016
Same author

Pattern of bloodstream infections in patients with hematological malignancies in a tertiary care centre.

Indian journal of cancer·2016
Same author

Guidelines for treatment of recurrent or metastatic head and neck cancer.

Indian journal of cancer·2014
Same journal

Indian Expert Consensus on Allergic Rhinitis in Women: A Modified Delphi Survey.

The Journal of the Association of Physicians of India·2026
Same journal

Systematic Review of Topical Capsaicin 0.075% for the Treatment of Neuropathic Pain: Efficacy, Safety, and Tolerability.

The Journal of the Association of Physicians of India·2026
Same journal

Sodium-Glucose Cotransporter 2 Inhibitors in Kidney Diseases Other Than That Due to Diabetes: Benefits in Composite Renal Outcomes Driven by Immunoglobulin A Nephropathy.

The Journal of the Association of Physicians of India·2026
Same journal

<i>Fasciolopsis buski</i> Diagnosed by Upper Gastrointestinal Endoscopy.

The Journal of the Association of Physicians of India·2026
Same journal

"Academic Overdose" among Healthcare Professionals.

The Journal of the Association of Physicians of India·2026
Same journal

Respiratory Examination for Postgraduate Residents: Unrevealing Expert's Questions and Answers.

The Journal of the Association of Physicians of India·2026
See all related articles

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Acute promyelocytic leukemia (APML) is characterized by a specific chromosomal translocation.
  • This translocation results in the PML/RAR-alpha fusion gene.
  • Coagulopathy is a frequent and dangerous complication of APML.

Purpose of the Study:

  • To evaluate the efficacy of all-trans retinoic acid (ATRA) in inducing clinical remission in APML.
  • To explore the role of the PML/RAR-alpha fusion gene in ATRA therapy sensitivity.
  • To investigate the impact of ATRA on APML-associated coagulopathy.

Main Methods:

  • Clinical assessment of remission in APML patients treated with ATRA.
  • Detection of the PML/RAR-alpha fusion gene as a predictive marker.

Related Experiment Videos

  • Monitoring of coagulation parameters during ATRA therapy.

    • Main Results:

    • ATRA demonstrated high effectiveness in inducing clinical remission in APML.
    • The presence of the PML/RAR-alpha fusion gene correlated with ATRA sensitivity.
    • ATRA rapidly resolved the coagulopathy associated with APML, reducing hemorrhage risk.

    Conclusions:

    • ATRA is a highly effective treatment for APML, inducing remission and resolving coagulopathy.
    • The PML/RAR-alpha fusion gene is a key marker for ATRA responsiveness.
    • ATRA's success in APML offers a paradigm for differentiation therapy in other malignancies.