Related Experiment Videos
Repeated naltrexone administration accelerates resolution of morphine somatic withdrawal signs in morphine-dependent
A L Muntoni1, M Diana, G L Gessa
1B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.
European Journal of Pharmacology
|April 22, 1996
Abstract:
Morphine-dependent rats were divided into two subgroups. The first was allowed to develop a spontaneous withdrawal syndrome which was still present 33 h after the last morphine administration. The second subgroup received five injections of naltrexone. While the first two injections of naltrexone precipitated a marked somatic withdrawal syndrome, subsequent naltrexone failed to worsen the somatic signs. 24 h after the last morphine administration, naltrexone was completely ineffective. It is concluded that naltrexone shortens the duration of the morphine somatic withdrawal signs in dependent rats.