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Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance
J W Hugg1, R I Kuzniecky, F G Gilliam
1UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham 35294-0021, USA.
Abstract:
We studied 10 medically intractable temporal lobe epilepsy (TLE) patients prior to surgery using proton magnetic resonance spectroscopic imaging (MRSI) to localize seizure foci. We found significantly elevated creatine/N-acetylaspartate (Cr/NAA) unilaterally in 8 and bilaterally in 2 patients. Five patients have been studied again 1 year after surgery. In the 2 patients with bilateral temporal seizure onsets, MRSI showed normalization of Cr/NAA in the unoperated contralateral tissue following surgical elimination of seizures. This study suggests that metabolic recovery can occur in contralateral temporal areas following surgical treatment of partial epilepsy.