Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Salivary glands and human selection: a hypothesis

E D Shields1, R W Mann

  • 1Department of Oral Biology, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.

Journal of Craniofacial Genetics and Developmental Biology
|April 1, 1996
PubMed
Summary

Stafne static bone defect (SSBD) may result from salivary gland factors, not just bone lesions. This common male defect suggests a genetic link influencing salivary gland size and human evolution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aplasia of the os odontoideum: Skeletal manifestation from Thailand.

International journal of paleopathology·2018
Same author

An electrohydraulic knee-torque controller for a prosthesis simulator.

Journal of biomechanical engineering·2013
Same author

FRONTAL TUMOURS.

Canadian Medical Association journal·2010
Same author

The Modern Laboratory Investigation of a Nephritic.

Canadian Medical Association journal·2010
Same author

Bright's Disease in Practice.

Canadian Medical Association journal·2010
Same author

A Resume of Diabetes Mellitus.

Canadian Medical Association journal·2010

Area of Science:

  • Oral and Maxillofacial Surgery
  • Evolutionary Biology
  • Genetics

Background:

  • Stafne static bone defect (SSBD) is a unique, localized, nonprogressive, and nonhealing mandibular bone lesion.
  • SSBD is more prevalent in males and occurs near major salivary glands, which produce bioactive factors.

Purpose of the Study:

  • To investigate the hypothesis that SSBD is caused by localized "leaks" of osteoclast-inducing factors from major salivary glands.
  • To explore the role of salivary gland size and genetic factors in SSBD and human evolutionary selection processes.

Main Methods:

  • Analysis of SSBD cases in relation to major salivary glands and mandibular immobility.
  • Correlation of SSBD prevalence with androgen-induced salivary gland enlargement and human population genetics.

Main Results:

  • A theory is proposed where mandibular immobility or enlarged salivary glands cause localized leakage of osteoclast induction factors.
  • Positive selection is linked to enlarged salivary glands (indicated by SSBD prevalence in males), correlating with environmental factors and infection clines.
  • Negative selection is observed in African American ancestors, where a mutation for larger salivary glands in both sexes conferred survival advantages against enteric diseases.

Conclusions:

  • SSBD is suggested to be a polymorphism and a marker for selection processes affecting major salivary gland size and structure.
  • The study posits a novel pathogenic mechanism for SSBD involving salivary gland secretions and links it to human evolutionary adaptations.

Related Experiment Videos