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Nitrite/nitrate (NOx) and sFas antigen levels in patients with multiple organ failure
1Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Abstract:
We assessed the plasma levels of nitrite/nitrate (NOx) and soluble Fas antigen (sFas) in patients with multiple organ failure (MOF). The NOx levels showed high levels in MOF patients with sepsis and without infection. A significant difference was not seen between the MOF patients complicated by sepsis and uncomplicated by infection, although the NOx levels in the former group tended to be higher. There was a significant correlation between NOx levels and sFas levels in MOF patients. Both sFas and NOx levels were high during MOF, and rapidly decreased when MOF was relieved. These findings suggest that sFas and NOx contribute to the development of MOF.
Insights
Elevated nitrite/nitrate (NOx) and soluble Fas antigen (sFas) levels are linked to multiple organ failure (MOF). These biomarkers decreased as MOF resolved, suggesting their role in MOF development.
Area of Science:
- Biochemistry
- Pathophysiology
- Critical Care Medicine
Background:
- Multiple organ failure (MOF) is a critical condition with high mortality.
- The underlying mechanisms of MOF are not fully understood.
- Nitrite/nitrate (NOx) and soluble Fas antigen (sFas) are potential biomarkers in critical illness.
Purpose of the Study:
- To investigate the plasma levels of NOx and sFas in patients with MOF.
- To explore the relationship between NOx, sFas, and the presence of sepsis in MOF patients.
- To determine if NOx and sFas levels correlate with MOF severity and resolution.
Main Methods:
- Plasma samples were collected from patients diagnosed with MOF.
- Nitrite/nitrate (NOx) levels were measured.
- Soluble Fas antigen (sFas) levels were quantified.
- Statistical analyses were performed to compare levels between patient groups and assess correlations.
Main Results:
- MOF patients exhibited elevated plasma NOx levels, particularly those with sepsis.
- While not statistically significant, NOx levels tended to be higher in MOF patients with sepsis compared to those without infection.
- A significant positive correlation was observed between plasma NOx and sFas levels in MOF patients.
- Both NOx and sFas levels were markedly high during active MOF and decreased substantially upon clinical improvement.
Conclusions:
- Elevated plasma NOx and sFas are associated with the presence and severity of multiple organ failure.
- These findings suggest that NOx and sFas play a contributory role in the pathophysiology of MOF.
- Monitoring NOx and sFas may offer insights into MOF progression and treatment response.