Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progressive supranuclear palsy presenting with dynamic aphasia

T Esmonde1, E Giles, J Xuereb

  • 1Department of Neurology, Royal Victoria Hospital, Belfast, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|April 1, 1996
PubMed
Summary

Some patients with progressive supranuclear palsy (PSP) initially present with language output difficulties, not typical motor symptoms. This suggests selective cognitive impairments affecting speech initiation in PSP.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Infliximab in Crohn's is associated with decreased intestinal surgery and similar health care costs.

Scandinavian journal of gastroenterology·2021
Same author

Coercive parenting: modifiable and nonmodifiable risk factors in parents of children with developmental disabilities.

Journal of intellectual disability research : JIDR·2021
Same author

Shielding patients from dental trauma.

British dental journal·2019
Same author

Deep sequencing shows low-level oncogenic hepatitis B virus variants persists post-liver transplant despite potent anti-HBV prophylaxis.

Journal of viral hepatitis·2018
Same author

Use of continuous fetal heart rate monitoring during discectomy at 24weeks of gestation.

International journal of obstetric anesthesia·2015
Same author

71-year-old male with progressive dyspnoea and peripheral oedema: a case of cardiac amyloidosis.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2015

Area of Science:

  • Neurology
  • Neuropsychology

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by motor deficits like unsteadiness and bradykinesia.
  • While dysarthria is common, significant language disorders are less recognized in PSP.

Observation:

  • This study reports on three patients with PSP where initial symptoms included pronounced difficulties with language output.
  • Pathological confirmation was obtained in two of the three reported cases.

Findings:

  • Neuropsychological assessments revealed significant impairments in tasks requiring active language initiation and retrieval, such as verbal fluency and narrative production.
  • Conversely, tasks like picture naming, verbal description comprehension, and sentence comprehension remained largely intact.
  • Semantic memory impairment was minimal in these patients.

Related Experiment Videos

Implications:

  • These findings suggest that some PSP patients may experience selective cognitive deficits affecting language planning and initiation.
  • This presentation mimics 'verbal adynamia' or 'dynamic aphasia' typically associated with frontal lobe damage.
  • The observed neuropsychological deficits likely stem from functional frontal deafferentation due to disrupted frontostriatal pathways.