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Related Experiment Videos

Non-ketotic hyperglycaemic chorea: a SPECT study

M H Chang1, J Y Li, S R Lee

  • 1Section of Neurology, Veterans General Hospital-Kaohsiung, Taiwan.

Journal of Neurology, Neurosurgery, and Psychiatry
|April 1, 1996
PubMed
Summary
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Regional brain blood flow in non-ketotic hyperglycaemic chorea patients showed decreased striatal blood flow on the side opposite to chorea. This suggests striatal hypofunction may be a common cause of chorea across different conditions.

Area of Science:

  • Neuroscience
  • Nuclear Medicine
  • Metabolic Disorders

Background:

  • Chorea is a movement disorder characterized by involuntary, irregular, and purposeless movements.
  • Non-ketotic hyperglycaemic chorea is a rare condition associated with high blood sugar levels.
  • The exact pathophysiology of chorea in hyperglycaemic states is not fully understood.

Purpose of the Study:

  • To investigate regional cerebral blood flow in the striatum of patients with non-ketotic hyperglycaemic chorea.
  • To compare striatal blood flow in hyperglycaemic chorea patients with a control group having similar hyperglycemia but without chorea.
  • To explore the potential role of striatal hypofunction in the pathogenesis of chorea.

Main Methods:

  • Brain SPECT (Single-Photon Emission Computed Tomography) imaging was utilized.

Related Experiment Videos

  • 99mTc hexamethylpropylene amineoxime was administered intravenously.
  • Six patients with non-ketotic hyperglycaemic chorea and 10 control subjects were included.
  • Focal perfusion defects were assessed visually and semi-quantitatively.

    • Main Results:

    • Significantly decreased striatal blood flow was observed on the side contralateral to the chorea.
    • SPECT imaging revealed hypoperfusion in the striatum of affected patients.
    • The control group with hyperglycemia but no chorea did not exhibit similar patterns of reduced striatal blood flow.

    Conclusions:

    • Striatal hypometabolism is implicated in non-ketotic hyperglycaemic chorea, similar to Huntington's disease.
    • Striatal hypofunction may represent a common pathogenic mechanism underlying contralateral chorea in various diseases.
    • SPECT demonstrates comparable sensitivity and reliability to PET for assessing patients with chorea.