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Occurrence of Graves' disease during retreatment with interferon-alpha 2a for chronic hepatitis C
M Wada1, W Hiraizumi, M Fujimoto
1Fourth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya.
Internal Medicine (Tokyo, Japan)
|November 1, 1995
Abstract:
The present report describes a patient who developed Graves' disease 3 months after inception of retreatment with higher doses of interferon-alpha 2a for chronic hepatitis C, although the initial 6-month treatment caused no serious adverse reactions. Severe hyperthyroidism continued despite discontinuation of interferon-alpha 2a, and the patient was subsequently treated with 131I. This case suggests careful evaluation of the safety of retreatment to prevent manifestation of such a complication in the retreatment of chronic hepatitis C with interferon.