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Related Experiment Videos

Neurological decompression illness in swine

J R Broome1, E J Dick

  • 1Naval Medical Research Institute, Bethesda, MD 20889-5067, USA.

Aviation, Space, and Environmental Medicine
|March 1, 1996
PubMed
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A new porcine model simulates severe neurological decompression illness (DCI) in divers. This model helps evaluate treatments for DCI, though recovery rates remain low.

Area of Science:

  • Diving Medicine
  • Animal Models
  • Neurology

Background:

  • Decompression illness (DCI) poses risks to divers.
  • A validated porcine model for neurological DCI is needed.
  • This study describes a novel porcine model for DCI.

Purpose of the Study:

  • To establish and characterize a porcine model of neurological DCI.
  • To evaluate the efficacy of recompression therapy (U.S. Navy Treatment Table 6).
  • To assess the impact of adjunctive lidocaine on DCI outcomes.

Main Methods:

  • Pigs simulated a 200 fsw dive followed by rapid decompression.
  • Neurological DCI was induced and treated with diazepam and recompression.
  • Functional recovery, carcass density, and histopathology were assessed.

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Main Results:

  • Neurological DCI occurred in 73% of control animals.
  • Only 16.4% of treated pigs achieved full functional recovery.
  • Histopathology revealed spinal cord hemorrhages in 86.6% of DCI cases.

Conclusions:

  • The porcine model mimics severe, early-onset human neurological DCI.
  • The model facilitates prospective studies on DCI risk reduction and treatment.
  • It is adaptable for studying hypobaric DCI and hyperbaric oxygen applications.