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Paraganglioma of the urinary bladder
Urologia Internationalis
|January 1, 1996
Summary
A rare urinary bladder paraganglioma presented with voiding symptoms. Transurethral resection was successful, with no recurrence after 2 years, highlighting effective management of this rare tumor.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Paragangliomas are rare neuroendocrine tumors originating from chromaffin cells.
- Urinary bladder paragangliomas are exceptionally rare, often presenting with nonspecific symptoms.
Observation:
- A 60-year-old woman presented with irritative voiding symptoms, lacking hematuria or hypertension.
- Sonography and cystoscopy identified a well-defined mass on the posterior bladder wall covered by normal mucosa.
Findings:
- Histological examination revealed nests of spindle cells with inconspicuous mitotic activity.
- Immunohistochemistry confirmed tumor cells positive for neuron-specific enolase and chromogranin A, negative for cytokeratin, vimentin, neurofilaments, GFAP, and HMB 45.
- Sustentacular cells tested positive for S-100 protein.
Implications:
- Transurethral resection proved an effective treatment modality for this bladder paraganglioma.
- The patient remained recurrence-free for 2 years post-surgery.
- This case underscores the importance of considering rare tumors in the differential diagnosis of bladder masses.