Prognostic factors in endometrial neoplasia: old and new

Factors of predictive, prognostic value in endometrial neoplasia are classic clinicopathological correlates, such as cytological and architectural atypia and special variants of adenocarcinoma, as well as the extent of invasion and spread. Advances in molecular biology in the field of oncogenes, cell proliferation studies, and so on have, as yet, failed to provide an alternative to traditional prognostic parameters. The overvaluation of these data may lead to overtreatment.