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A novel cDNA isolated from the mouse eye lens encoding a protein with zinc fingers and a KRAB domain
1Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730, USA.
DNA Sequence : the Journal of DNA Sequencing and Mapping
|January 1, 1995
Abstract:
A cDNA clone, pMLZ-8, was isolated from a newborn mouse eye lens cDNA library using a consensus zinc finger oligonucleotide hybridization probe. The cDNA contains an open reading frame that conceptually encodes a 606 amino acid protein. The protein possesses a "KRAB" domain at its amino-terminus and has a carboxy-terminal region with fifteen consensus C2H2 zinc fingers. PCR analysis reveals the presence of pMLZ-8 mRNA in lens, liver, kidney, spleen, and brain of newborn mice.
