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Establishment of an Extracellular Acidic pH Culture System
09:41

Establishment of an Extracellular Acidic pH Culture System

Published on: November 19, 2017

Organic acidosis in infants

L A Barness

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |May 14, 1977
    PubMed

    Insights

    Persistent acidosis in children and adults may indicate organic aciduria, necessitating urgent diagnosis for treatable conditions. Early detection and specific fluid therapy can correct acidosis, potentially avoiding bicarbonate use.

    Area of Science:

    • Biochemistry
    • Pediatrics
    • Internal Medicine

    Background:

    • Persistent acidosis after treatment suggests underlying organic aciduria.
    • Acidosis is also observed in hypoperfusion states.
    • Early diagnosis is critical due to available treatments for some organic acidurias.

    Purpose of the Study:

    • To highlight the importance of suspecting organic aciduria in specific clinical scenarios.
    • To emphasize the urgency of early diagnosis for treatable organic acidurias.
    • To present an alternative treatment for acidosis in hypoperfused states.

    Main Methods:

    • Clinical suspicion based on persistent acidosis and large anion gap.
    • Assessment of hypoperfusion states.
    • Treatment of hypoperfusion with specific saline and potassium solution.

    Main Results:

    • Suspecting organic aciduria is crucial for persistent acidosis or large anion gap acidosis.
    • Fluid therapy with saline and potassium can correct acidosis in hypoperfusion.
    • Bicarbonate may not be necessary when treating hypoperfusion effectively.

    Conclusions:

    • Organic aciduria should be considered in persistent acidosis cases.
    • Prompt diagnosis of organic aciduria is vital for timely intervention.
    • Saline-potassium treatment is an effective alternative for acidosis in hypoperfusion.

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