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Transient glutamic acidaemia

A R Franz1, F Pohlandt

  • 1Neonatologie und pädiatrische Intensivmedizin, Universitätskinderklinik, Ulm, Germany.

European Journal of Pediatrics
|April 1, 1996
PubMed
Summary
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A rare condition called transient glutamic acidaemia in newborns causes high plasma glutamate levels. This condition appears to have no negative impact on infant development.

Area of Science:

  • Biochemistry
  • Neonatology
  • Metabolic Disorders

Background:

  • Persistent diarrhea and metabolic acidosis in neonates can indicate underlying metabolic disturbances.
  • Elevated plasma amino acid concentrations require thorough investigation to rule out metabolic defects.

Observation:

  • A severely hypotrophic male twin presented with persistent diarrhea and metabolic acidosis in the first four weeks of life.
  • Plasma glutamate levels were fivefold higher than normal in the affected infant.
  • The infant's dizygotic twin sibling and parents showed no clinical or biochemical abnormalities.

Findings:

  • Further investigations excluded major defects in amino acid metabolism.
  • Plasma glutamate concentrations normalized by five months of age.

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  • The condition, transient glutamic acidaemia, is extremely rare in newborns.

    • Implications:

    • Transient glutamic acidaemia in infants appears to be a benign condition.
    • This condition does not seem to negatively impact physical and neurological development in early infancy.