[Certain biochemical markers in women with abnormal states of the reproductive system]

The concentrations of collagen, hydroxyproline, glycosaminoglycans and estradiol were determined in 60 women aged 51 to 60 years (mean: 55.6 +/- 4.4). When compared with values from women with normal statics with women with lowered statics of the genital organ demonstrated significantly lower concentration of collagen (p < 0.05) in the teres ligaments. Women with prolapse of the genital organ had significantly lower concentration of estradiol in serum (p < 0.001) and of collagen (p < 0.01) in the teres ligaments, with significantly higher daily excretion of hydroxyproline (p < 0.01) and glycosaminoglycans (p < 0.001) in urine. In women with prolapse of the genital organ a significantly positive correlation between the concentration of estradiol and collagen (r = 0.76; p < 0.05) and negative correlation between the concentration of estradiol and hydroxyproline (r = -0.59; p < 0.05) and glycosaminoglycans (r = -0.61; p < 0.05) has been found.