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HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana
J L McCormick1, T C McKee, J H Cardellina
1Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Journal of Natural Products
|May 1, 1996
Abstract:
Bioassay-directed fractionation of the CH2Cl2-MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3-5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 microM, respectively), but 3-5 were inactive against HIV-1.