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Coriadienin, the first annonaceous acetogenin with two double bonds isolated from Annona coriaceae
E L Meneses da Silva1, F Roblot, J Mahuteau
1Laboratoire de Pharmacognosie et Service de RMN, Faculté de Pharmacie, Châtenay-Malabry, France.
Journal of Natural Products
|May 1, 1996
Abstract:
A new Annonaceous acetogenin, coriadienin (1), has been isolated from the roots of Annona coriacea Mart. (Annonaceae). This structure is the first reported acetogenin containing two double bonds. Compound 1 showed potent cytotoxicity against VERO and KB cell lines. Compound 1 appears to play an important role in the biosynthetic pathway of mono- and bis-THF acetogenins, and it is proposed as a biogenetic precursor of coriacin. A known cytotoxic acetogenin, gigantetronenin, was also isolated from this plant.