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Apparent heparin resistance form elevated factor VIII in a patient with postoperative deep venous thrombosis. A case
F D Cirisano1, S Lee, J S Greenspoon
1Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
The Journal of Reproductive Medicine
|March 1, 1996
Abstract
Background:
During the puerperium, heparin levels, rather than the adjusted partial thromboplastin time test, can be used to identify heparin resistance and guide heparin therapy.
Case:
A patient receiving heparin for deep venous thrombosis had artifactual resistance to heparin, with a short adjusted partial thromboplastin time due to elevation of factor VIII. Heparin assay revealed a heparin level above the therapeutic range.
Conclusion:
Direct measurement of heparin concentration and factor VIII activity should be performed when heparin resistance is suspected.