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[Chronic persistent coughing successfully treated with ozagrel]

K Nishi1, M Mizuguchi, H Tachibana

  • 1Division of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.

Nihon Kyobu Shikkan Gakkai Zasshi
|March 1, 1996
PubMed
Summary
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A persistent cough in a young woman was unresponsive to standard treatments. A thromboxane synthetase inhibitor effectively eliminated the cough, suggesting thromboxane A2

Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Chronic cough is a common respiratory symptom.
  • Refractory cough cases often require investigation into alternative etiological factors.

Observation:

  • A 25-year-old woman presented with a persistent cough lasting over 8 weeks.
  • Her cough did not improve with clenbuterol (a beta 2-adrenoceptor agonist), azelastine (an anti-allergic agent), or an inhaled corticosteroid.

Findings:

  • Treatment with ozagrel, a thromboxane synthetase inhibitor, completely resolved the patient's cough.
  • This suggests a potential role for thromboxane A2 in the pathogenesis of her cough.

Implications:

  • Thromboxane A2 may be a contributing factor in some cases of refractory chronic cough.

Related Experiment Videos

  • This finding could open new therapeutic avenues for managing unexplained persistent cough.