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The mechanistic rationale in support of dietary cancer prevention
1Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, New York 10595, USA.
Preventive Medicine
|January 1, 1996
Abstract:
Mechanistic studies are an essential component of dietary cancer prevention trials. In breast and prostate cancer, a low-fat diet with a reduction in omega-6 fatty acid may prove effective, not only because of related decreases in sex steroid hormones, but as a result of altered eicosanoid biosynthesis. An optimal approach to primary and secondary prevention is likely to be a dietary change combined with one or more pharmacologically based chemopreventive agents. Patients with in situ carcinoma of the breast or prostate are candidates for dietary intervention as a means of secondary prevention.