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Preavoidance hypercapnia and decreased hematocrit in micropigs

D E Anderson1, O V Fedorova, A W French

  • 1Laboratory of Behavioral Sciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA.

Physiology & Behavior
|April 1, 1996
PubMed
Summary

Behavioral stress in micropigs causes significant changes in blood pressure, heart rate, and blood gases. These physiological responses, including hypercapnia, may play a role in blood pressure regulation.

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Area of Science:

  • Physiology
  • Behavioral Science
  • Animal Models

Background:

  • Previous research in dogs indicated stress-induced physiological changes not fully explained by adrenergic antagonists.
  • The physiological responses to pre-avoidance stress in dogs included increased blood pressure and decreased heart rate and respiration.

Purpose of the Study:

  • To investigate if micropigs exhibit similar blood pressure and heart rate changes as dogs before an avoidance task.
  • To characterize the changes in blood gases, plasma pH, bicarbonate, hematocrit, and electrolytes during pre-avoidance and avoidance periods in micropigs.

Main Methods:

  • Micropigs were subjected to pre-avoidance periods followed by avoidance task sessions.
  • Continuous monitoring of blood pressure and heart rate.
  • Analysis of blood gases (pO2, pCO2), plasma pH, bicarbonate, hematocrit, and electrolytes.

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Main Results:

  • Blood pressure increased and heart rate decreased during pre-avoidance periods.
  • Both blood pressure and heart rate were elevated during avoidance periods.
  • Pre-avoidance induced decreased pO2, plasma pH, and plasma potassium, with increased pCO2 and bicarbonate, and decreased hematocrit.

Conclusions:

  • Micropigs exhibit distinct cardiovascular and blood gas changes in response to pre-avoidance stress.
  • Behaviorally induced hypercapnia may influence blood pressure regulation through renal mechanisms.
  • Findings suggest a role for hypercapnia in modulating renal sodium handling and retention.