Related Experiment Videos
[AB-cis phenotype with expression similar to AB-el]
J González Campos1, J M Jiménez Jiménez, F Caso Sanz
1Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Sevilla.
Sangre
|February 1, 1996
Summary
A blood group discrepancy between red blood cells and serum was resolved. The individual possesses a rare cis-AB blood group with a weak B antigen variant, known as Bel.
Area of Science:
- Immunology
- Genetics
- Hematology
Background:
- Blood group discrepancies between red cell and serum testing can indicate rare antigen variants.
- Accurate blood typing is crucial for safe blood transfusions and transplantation.
Observation:
- A patient presented with conflicting red cell (Group A) and serum (Group AB) typing results.
- Further serological testing, including adsorption-elution and saliva tests, was performed to investigate the discrepancy.
Findings:
- The comprehensive analysis confirmed the blood group as AB.
- A weak B antigen variant, identified as Bel, was detected.
- Genetic analysis of parental blood groups (mother AB, father O) supported the findings.
Implications:
- This case highlights the importance of investigating discordant blood typing results.
- Identification of the cis-AB phenotype and weak Bel variant is significant for transfusion medicine.
- Understanding rare blood group phenotypes aids in managing transfusion reactions and donor selection.