Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The extracellular matrix and its modulation in the trabecular meshwork

B Y Yue1

  • 1University of Illinois at Chicago, Department of Ophthalmology and Visual Sciences, Lions of Illinois Eye Research Institute, Chicago, USA.

Survey of Ophthalmology
|March 1, 1996
PubMed
Summary

Abnormal extracellular matrix (ECM) in the eye's trabecular meshwork is linked to primary open-angle glaucoma. Understanding ECM composition and its modulation is key to addressing outflow resistance and glaucoma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of glycosaminoglycan-degrading enzymes on bovine trabecular meshwork in organ culture.

Journal of glaucoma·2009
Same author

Keratocan expression is increased in the stroma of keratoconus corneas.

Molecular medicine (Cambridge, Mass.)·2001
Same author

Expression of type XII collagen and hemidesmosome-associated proteins in keratoconus corneas.

Current eye research·2001
Same author

Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.

Archives of ophthalmology (Chicago, Ill. : 1960)·2001
Same author

Involvement of Sp1 elements in the promoter activity of genes affected in keratoconus.

Investigative ophthalmology & visual science·2001
Same author

Cell density regulated expression of transcription factor Sp1 in corneal stromal cultures.

Experimental eye research·2001

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biochemistry

Background:

  • The extracellular matrix (ECM) in the trabecular meshwork is crucial for maintaining normal aqueous humor outflow.
  • Abnormal accumulations of ECM materials are observed in the trabecular meshwork of patients with primary open-angle glaucoma (POAG).

Purpose of the Study:

  • To review current knowledge on trabecular meshwork ECM composition and its protein receptors.
  • To describe how aqueous humor constituents and glucocorticoids modulate ECM elements.
  • To explore the relationship between ECM modulation and trabecular meshwork cell function in relation to outflow resistance.

Main Methods:

  • Literature review of studies on trabecular meshwork ECM.
  • Analysis of ECM composition and receptor identification.

Related Experiment Videos

  • Examination of ECM modulation by aqueous humor components and glucocorticoids.

    • Main Results:

    • The ECM plays a significant role in regulating trabecular meshwork cell behavior.
    • Specific ECM components and their receptors are implicated in glaucoma pathogenesis.
    • Modulation of ECM by factors like glucocorticoids can alter trabecular meshwork function.

    Conclusions:

    • Understanding trabecular meshwork ECM composition and its regulation is vital for glaucoma research.
    • Further investigation into the functional consequences of ECM modulation is needed to clarify its relevance to outflow resistance in POAG.