Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paraventricular nucleus efferents influence area postrema neurons

P M Smith1, A V Ferguson

  • 1Department of Physiology, Queen's University, Kingston, Ontario, Canada.

The American Journal of Physiology
|February 1, 1996
PubMed
Summary

Stimulating the paraventricular nucleus (PVN) excites most area postrema (AP) neurons in rats. These findings highlight descending hypothalamic control over this key circumventricular organ.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skeletal muscle mitochondrial dysfunction is associated with increased Gdf15 expression and circulating GDF15 levels in aged mice.

Scientific reports·2025
Same author

The effect of age and sex on peak oxygen uptake during upper and lower body exercise: A systematic review.

Experimental gerontology·2024
Same author

Exploring the genetics underpinning dynamic laryngeal collapse associated with poll flexion in Norwegian-Swedish Coldblooded Trotter racehorses.

Equine veterinary journal·2019
Same author

The transcriptome of the rat subfornical organ is altered in response to early postnatal overnutrition.

IBRO reports·2018
Same author

The subfornical organ: A novel site for prolactin action.

Journal of neuroendocrinology·2018
Same author

A method for securing the temporary lead(s) in sacral nerve stimulation.

Annals of the Royal College of Surgeons of England·2017

Area of Science:

  • Neuroscience
  • Physiology

Background:

  • The area postrema (AP) is a circumventricular organ crucial for autonomic regulation.
  • Descending hypothalamic inputs are implicated in controlling AP neuronal activity.

Purpose of the Study:

  • To investigate the effects of paraventricular nucleus (PVN) stimulation on AP neurons.
  • To explore the role of hypothalamic projections in modulating AP function.

Main Methods:

  • Extracellular single-unit recordings were performed on AP neurons in anesthetized Sprague-Dawley rats.
  • Peristimulus histograms analyzed the response of AP neurons to PVN stimulation.
  • Control experiments involved stimulation at non-PVN sites.

Main Results:

  • PVN stimulation elicited short-latency excitation in 30.8% of tested AP neurons.

Related Experiment Videos

  • A smaller percentage (8.6%) of AP neurons showed inhibition following PVN stimulation.
  • PVN stimulation significantly influenced AP neurons more than non-PVN stimulation.
  • Conclusions:

    • Activation of PVN neurons exerts a predominantly excitatory influence on AP neurons.
    • Descending hypothalamic pathways play a significant role in regulating AP neuronal activity.