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Related Experiment Videos

MRI signal hyperintensities in geriatric depression

B S Greenwald1, E Kramer-Ginsberg, R R Krishnan

  • 1Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA.

The American Journal of Psychiatry
|September 1, 1996
PubMed
Summary

Elderly depressed patients show more severe subcortical gray matter hyperintensities on MRI scans. These brain changes are linked to cerebrovascular disease risk and age, not depression onset.

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Area of Science:

  • Neuroimaging
  • Geriatric Psychiatry

Background:

  • Depression in the elderly is a significant public health concern.
  • Neuroimaging studies suggest structural brain changes may be associated with depression.

Purpose of the Study:

  • To investigate if MRI-detected signal hyperintensities differentiate elderly depressed patients from controls.
  • To explore the association between hyperintensities and clinical variables in geriatric depression.

Main Methods:

  • Magnetic resonance imaging (MRI) scans were analyzed in 48 elderly patients with depression (DSM-III-R) and 39 normal elderly subjects.
  • Two established rating systems were used to assess periventricular and subcortical signal hyperintensities.

Main Results:

  • Elderly depressed patients exhibited significantly more severe subcortical gray matter hyperintensities compared to controls.

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  • No significant differences in hyperintensities were found between early-onset and late-onset depression in patients with similar age and cerebrovascular risk.

    • Conclusions:

    • Findings support the involvement of basal ganglia in geriatric depression.
    • The association between late-onset depression and MRI hyperintensities is likely influenced by cerebrovascular disease risk and age.