Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The effect of exercise on ob gene expression

D Zheng1, M H Wooter, Q Zhou

  • 1Department of Biochemistry, East Carolina University School of Medicine, Greenville, North Carolina 27858, USA.

Biochemical and Biophysical Research Communications
|August 23, 1996
PubMed
Summary

Exercise transiently reduces ob gene expression, which regulates fat storage. This effect may help manage energy balance after physical activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Mechanism study of S100A4 influencing pulmonary fibrosis through the lncRNA MEG3/miR-147 pathway].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2026
Same author

Retraction Note: Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol.

Oncogene·2026
Same author

[Demographic characteristic and clinical features in 1 812 patients with salivary gland stones].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026
Same author

Residue of <i>Erycibe obtusifolia Benth</i> as bedding materials improves welfare and microorganisms of chickens.

British poultry science·2025
Same author

High-HDAC7 expression related to poor prognosis in sinonasal mucosal melanoma.

Rhinology·2025
Same author

[A meta-analysis of the efficacy and safety of genicular artery embolization for the treatment of pain secondary to knee osteoarthritis].

Zhonghua yi xue za zhi·2024

Area of Science:

  • Physiology
  • Molecular Biology
  • Endocrinology

Background:

  • The ob gene encodes leptin, a hormone crucial for regulating fat storage and energy balance.
  • Leptin production is influenced by nutritional status and hormonal signals.
  • Understanding how lifestyle factors like exercise affect ob gene expression is important for metabolic health.

Purpose of the Study:

  • To investigate the impact of acute exercise and long-term exercise training on ob mRNA levels in rat adipose tissue.
  • To determine the temporal effects of exercise on ob gene expression.

Main Methods:

  • Northern blot analysis was used to quantify ob mRNA levels.
  • Experiments involved a single bout of exercise and a 4-week exercise training program in rats.

Main Results:

  • A single exercise session significantly decreased ob mRNA levels by approximately 30% immediately and 3 hours post-exercise.
  • Four weeks of exercise training resulted in a significant decrease of approximately 48% in ob mRNA levels 2 hours after the final training session compared to controls.

Conclusions:

  • Exercise exerts a transient inhibitory effect on ob gene expression in adipose tissue.
  • The regulation of ob gene expression by exercise may play a role in controlling energy balance following physical activity.

Related Experiment Videos