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Effect of X-ray irradiation on proliferation and differentiation of osteoblast
S Matsumura1, A Jikko, H Hiranuma
1Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Osaka University, Japan.
Calcified Tissue International
|October 1, 1996
Abstract:
We exposed the osteoblast-like cell line, MC3T3-E1, to 1-to 10-Gy X-ray. Irradiation at doses of 5-Gy dose or stage, confluence, and post-proliferation stages. The alkaline phosphatase activity, conversely, was increased by irradiation, and the calcium content of irradiated cells was greater than that of nonirradiated. These findings suggest that irradiation induces terminal differentiation and calcification of osteoblasts.