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Updated: Aug 19, 2026

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Published on: January 18, 2018
Catheter-directed thrombolysis with recombinant tissue plasminogen activator for acute pulmonary embolism after
1Department of Pediatric Cardiology, Kinderklinik, University of Graz, Auenbruggerplatz, A-8036 Graz, Austria.
Abstract:
We report the case of a 3-year-old girl who presented with near-lethal pulmonary thrombembolism 3 weeks after an uneventful Fontan operation. Complete occlusion of the left lower lobe pulmonary artery had occurred together with a cerebral infarction. Recombinant tissue plasminogen activator (rt-Pa) was used for thrombolysis because of its short half-life and its clot-selective properties. To further minimize the systemic effects of rt-PA, local catheter-directed lysis was performed. A prolonged course of low-dose rt-PA therapy achieved complete lysis without side effects.
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