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Neurogenic amplification of immune complex inflammation
1Perlmutter Laboratory, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Science (New York, N.Y.)
|September 20, 1996
Abstract:
The formation of intrapulmonary immune complexes in mice generates a vigorous inflammatory response characterized by microvascular permeability and polymorphonuclear neutrophil influx. Gene-targeted disruption of the substance P receptor (NK-1R) protected the lung from immune complex injury, as did disruption of the C5a anaphylatoxin receptor. Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung.