Histamine-induced cytosolic calcium increase in porcine articular chondrocytes

Chondrocytes have been shown to possess two types of histamine receptors, H1 and H2. The application of histamine to isolated porcine chondrocytes was found to significantly increase intracellular calcium and this increase was partially dependent upon the presence of extracellular calcium. This, therefore, implies that there is some role for a plasma membrane calcium transport system in the increase of cytosolic calcium in response to histamine. The increase in intracellular calcium in response to the application of histamine was found to be reduced by both H1 and H2 receptor antagonists.