Search research articles

Search research articles

Related Experiment Videos

C-peptide improves autonomic nerve function in IDDM patients

B L Johansson¹, K Borg, E Fernqvist-Forbes

¹Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden.

|June 1, 1996

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vision therapy as part of neurorehabilitation after acquired brain injury - a clinical study in an outpatient setting.

Brain injury·2020

Same author

Correction: Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1.

Leukemia·2020

Same author

Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1.

Leukemia·2019

Same author

Performance and digestive function of broiler chickens given grit in the diet.

British poultry science·2017

Same author

C-peptide and the pathophysiology of microvascular complications of diabetes.

Journal of internal medicine·2016

Same author

Polio Patients in Northern Italy, a 50 Year Follow-up.

The open neurology journal·2016

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Short-term C-peptide infusion improved autonomic nerve function in patients with insulin-dependent diabetes (IDDM). This study found enhanced heart rate variability and brake index, suggesting C-peptide may benefit diabetic polyneuropathy.

Area of Science:

Endocrinology
Neurology
Metabolic Disorders

Background:

Diabetic polyneuropathy is a common complication of insulin-dependent diabetes mellitus (IDDM).
C-peptide, a byproduct of insulin production, has been investigated for potential therapeutic roles in diabetes.
Autonomic nerve dysfunction is a significant aspect of diabetic polyneuropathy.

Purpose of the Study:

To investigate the influence of C-peptide on nerve function in patients with IDDM and symptoms of diabetic polyneuropathy.
To assess the effects of C-peptide infusion on autonomic nerve function, sensory thresholds, and nerve conduction.

Main Methods:

A double-blind study involving 12 IDDM patients with diabetic polyneuropathy.
Patients underwent tests of autonomic nerve function (respiratory heart rate variability, brake index), sensory thresholds, and nerve conduction before and during a 3-hour intravenous infusion of either C-peptide or saline.

Related Experiment Videos

Plasma C-peptide levels were monitored.

Main Results:

C-peptide infusion significantly increased respiratory heart rate variability and the brake index, indicating improved autonomic nerve function.
No significant changes were observed in clinical neurological examinations, sensory thresholds, or nerve conduction measurements.
Saline infusion did not produce similar improvements in autonomic function tests.

Conclusions:

Short-term (3-hour) infusion of C-peptide at physiological amounts may improve autonomic nerve function in patients with IDDM.
C-peptide shows potential as a therapeutic agent for managing autonomic neuropathy in diabetic patients.
Further research is warranted to explore the long-term effects and mechanisms of C-peptide in diabetic nerve complications.