Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

First-episode schizophrenia: I. Early course parameters

T K Larsen1, T H McGlashan, L C Moe

  • 1Psychiatric Hospital of Rogaland, Stavanger, Norway.

Schizophrenia Bulletin
|January 1, 1996
PubMed
Summary

This study on first-episode schizophrenia found long durations of untreated psychosis (DUP) are common and linked to worse functioning. Findings highlight gender differences in early schizophrenia symptoms and course.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of childhood trauma on antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, semi-randomized trial.

Schizophrenia research·2022
Same author

Persistent negative symptoms in youth at clinical high risk for psychosis: A longitudinal study.

Schizophrenia research·2020
Same author

Longitudinal changes in social cognition in individuals at clinical high risk for psychosis: An outcome based analysis.

Schizophrenia research·2018
Same author

Insights into psychosis risk from leukocyte microRNA expression.

Translational psychiatry·2016
Same author

Substance use in individuals at clinical high risk of psychosis.

Psychological medicine·2015
Same author

Alcohol confounds relationship between cannabis misuse and psychosis conversion in a high-risk sample.

Acta psychiatrica Scandinavica·2015

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Schizophrenia's early course is critical for long-term outcomes.
  • Understanding factors influencing the early stages of schizophrenia is essential for timely intervention.

Purpose of the Study:

  • To review concepts and definitions of schizophrenia's early course.
  • To present parameters of a first-episode schizophrenia sample.
  • To explore associations between duration of untreated psychosis (DUP) and functioning.

Main Methods:

  • Review of existing literature on early schizophrenia.
  • Analysis of a Norwegian first-episode schizophrenia sample (n=43).
  • Statistical assessment of gender differences and DUP correlations.

Main Results:

  • Significant gender differences observed in marital status, education, age at onset, and functioning.
  • The mean duration of untreated psychosis (DUP) was 114 weeks.
  • Longer DUP correlated with poorer functioning, insidious onset, and more negative symptoms, independent of gender.

Conclusions:

  • Long DUP is a significant issue in early schizophrenia, impacting patient outcomes.
  • Further research is needed to understand delayed treatment seeking.
  • Standardized measurement of early course parameters is recommended.

Related Experiment Videos