Asymmetric retinal growth: evidence for regulation by a retinotopic mechanism

Adult teleost retinas grow throughout life, in part by the addition of cells from an encircling, proliferative neuroepithelium. In some species, this proliferative growth is asymmetric around the retina. The present study evaluated two hypotheses regarding asymmetric proliferative growth in adult green sunfish retina: (1) the generation of rod photoreceptors in central retina from proliferative rod precursor cells is also asymmetric; and (2) asymmetric proliferative growth patterns are regulated by mechanisms that are organized retinotopically and are independent of body-axis coordinates. In all retinas examined, rod precursor distribution and rod production were asymmetric, and both were in coarse spatial register with the asymmetric pattern of cellular addition at the retinal margin. In adult eyes that were surgically rotated, the asymmetric patterns of proliferative growth were present and appropriate for the retina's prerotation orientation. The results suggest that proliferative growth at both marginal and central adult sunfish retina is asymmetric, and that these asymmetric growth patterns are regulated by a retinotopic mechanism that is independent of body-axis coordinates.