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The mortality of epilepsy

O C Cockerell1

  • 1The Epilepsy Research Group, National Hospital for Neurology, London, UK.

Current Opinion in Neurology
|April 1, 1996
PubMed
Summary

Patients with epilepsy face a 2-3 times higher risk of premature death. Epilepsy-related deaths, including sudden unexpected death, are a concern, but improved seizure control may reduce these risks.

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Area of Science:

  • Neurology
  • Public Health
  • Epidemiology

Background:

  • The risk of premature mortality in epilepsy patients is significantly elevated compared to the general population.
  • The majority of this increased risk is attributed to the underlying causes of epilepsy.
  • Epilepsy-related deaths, encompassing seizure-induced fatalities, accidents, and Sudden Unexpected Death in Epilepsy (SUDEP), represent a subset of this mortality.

Purpose of the Study:

  • To quantify the overall risk of premature death in patients with epilepsy.
  • To differentiate between epilepsy-related deaths and other causes of mortality in this population.
  • To explore potential strategies for mitigating epilepsy-related mortality.

Main Methods:

  • Quantification of mortality risk through epidemiological analysis.
  • Categorization of death causes in epilepsy patients.
  • Review of recent studies on risk reduction strategies.

Main Results:

  • Patients with epilepsy have a 2-3 fold increased risk of premature death.
  • Sudden Unexpected Death in Epilepsy (SUDEP) is more prevalent in cases of intractable epilepsy.
  • Interventions like improved seizure management and patient supervision show promise in reducing mortality.

Conclusions:

  • Epilepsy is associated with a substantially higher risk of premature death.
  • Targeted interventions focusing on seizure control and safety precautions can potentially lower the incidence of epilepsy-related deaths, including SUDEP.

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