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Trace elements and cardiovascular diseases

J P Houtman1

  • 1Interuniversity Reactor Institute, Delff, The Netherlands.

Journal of Cardiovascular Risk
|February 1, 1996
PubMed
Summary
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Trace elements impact human health, particularly cardiovascular disease risk. Selenium, copper, zinc, chromium, and manganese appear protective, while cadmium and lead may increase risk.

Area of Science:

  • Environmental Health
  • Human Physiology
  • Toxicology

Background:

  • The link between trace elements and human health, especially cardiovascular diseases, is under-researched.
  • Environmental contamination by trace elements can lead to long-term, low-level health effects.
  • Focus has been on elements like arsenic, cadmium, copper, chromium, lead, manganese, selenium, and zinc.

Purpose of the Study:

  • To review current knowledge on the relationship between trace elements and cardiovascular health.
  • To synthesize findings from epidemiological, biochemical, and cell biological studies.
  • To address interpretation challenges due to complex biochemical interactions and detoxification mechanisms.

Main Methods:

  • Review of epidemiological studies.

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  • Review of biochemical studies.
  • Review of cell biological studies.
  • Main Results:

    • Selenium, copper, zinc, chromium, and manganese generally appear to counteract cardiovascular disease development.
    • Cadmium and potentially lead may stimulate the development of cardiovascular diseases.
    • Effects of arsenic, silicon, and fluorine remain unclear; cobalt's effects are absent.

    Conclusions:

    • Certain trace elements play a role in cardiovascular health, with varying effects.
    • Individual vulnerability to trace element effects can be influenced by complex interactions and detoxification.
    • The public health impact is likely limited, barring exceptional contamination scenarios.