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Plasma-triglycerides do not regulate high-density lipoprotein concentrations
Diets high in carbohydrate and diets restricted in fat and calories were used to induce large fluctuations in plasma-triglycerides in patients with severe familial hypertriglyceridaemia. High-density-lipoprotein (HDL) concentrations were estimated by radioimmunoassay of the major HDL apoprotein, apo A-I, and were correlated with plasma cholesterol and triglyceride concentrations. Patients with type-1 hyperlipoproteinaemia had apo A-I concentrations about 50% of normal, and no increase in apo A-1 concentrations was observed even when plasmatriglycerides were reduced to the normal range. Apo A-I concentrations in type-5 hyperlipoproteinaemia were not consistently low and did not correlate with plasma-lipid concentrations. It does not seem that hypertriglyceridaemia reduces HDL in either disorder.
Diets high in carbohydrate and diets restricted in fat and calories were used to induce large fluctuations in plasma-triglycerides in patients with severe familial hypertriglyceridaemia. High-density-lipoprotein (HDL) concentrations were estimated by radioimmunoassay of the major HDL apoprotein, apo A-I, and were correlated with plasma cholesterol and triglyceride concentrations. Patients with type-1 hyperlipoproteinaemia had apo A-I concentrations about 50% of normal, and no increase in apo A-1 concentrations was observed even when plasmatriglycerides were reduced to the normal range. Apo A-I concentrations in type-5 hyperlipoproteinaemia were not consistently low and did not correlate with plasma-lipid concentrations. It does not seem that hypertriglyceridaemia reduces HDL in either disorder.