Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rotavirus vaccine: current status & future prospects

T N Naik1, T Krishnan

  • 1Division of Virology, National Institute of Cholera & Enteric Diseases, Calcutta.

The Indian Journal of Medical Research
|July 1, 1996
PubMed
Summary

Rotavirus vaccines for infant diarrhea show limited success due to poor heterotypic protection. Understanding neonatal immunity and viral strain evolution is key to improving rotavirus vaccine efficacy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for a Spectral Break or Curvature in the Spectrum of Astrophysical Neutrinos from 5 TeV to 10 PeV.

Physical review letters·2026
Same author

Search for Extremely-High-Energy Neutrinos and First Constraints on the Ultrahigh-Energy Cosmic-Ray Proton Fraction with IceCube.

Physical review letters·2025
Same author

Maternal Uterine Artery Adenoviral Vascular Endothelial Growth Factor (Ad.VEGF-A<sub>165</sub>) Gene Therapy Normalises Fetal Brain Growth and Microglial Activation in Nutrient Restricted Pregnant Guinea Pigs.

Reproductive sciences (Thousand Oaks, Calif.)·2024
Same author

Membrane disruption and anti-quorum sensing effects of synergistic interaction between Lavandula angustifolia (lavender oil) in combination with antibiotic against plasmid-conferred multi-drug-resistant Escherichia coli.

Journal of applied microbiology·2014
Same author

The role of leukemia inhibitory factor in tubal ectopic pregnancy.

Placenta·2013
Same author

Effect of temperature, relative humidity and rainfall on rotavirus infections in Kolkata, India.

Epidemiology and infection·2012

Area of Science:

  • Vaccinology
  • Immunology
  • Pediatrics

Background:

  • Rotavirus vaccines, including live attenuated, killed, and subunit types, have been developed to combat infantile diarrhea.
  • Global field trials have yielded moderate to limited success, with a notable lack of heterotypic protection in vaccine recipients.

Purpose of the Study:

  • To analyze the reasons behind the limited efficacy of current rotavirus vaccines.
  • To identify key factors influencing the failure of rotavirus vaccines in controlling infantile diarrhea.

Main Methods:

  • Review of existing rotavirus vaccine development and field trial data.
  • Analysis of immunological responses and viral characteristics.

Main Results:

  • Vaccinees frequently failed to develop broad-ranging (heterotypic) protection against diverse rotavirus strains.
  • Existing vaccine strategies have not adequately addressed critical aspects of the immune response and viral dynamics.

Conclusions:

  • The ineffectiveness of rotavirus vaccines may stem from an incomplete understanding of the neonatal mucosal immune system.
  • Viral evolution, including the emergence of reassortant strains and seasonal variations in prevalent types, poses significant challenges to vaccine control.

Related Experiment Videos