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Radioimmunoguided surgery and colorectal cancer
F Aftab1, H S Stoldt, A Testori
1Department of General Surgical Oncology, European Institute of Oncology, Milan, Italy.
Abstract:
Radioimmunoguided surgery is a technique that aims to delineate the extent of epithelial neoplasms (primary/recurrent) and their spread (local, regional, and distant) which are not adequately visualized by conventional imaging techniques. The target lesion binds radiolabelled, tumour-associated monoclonal antibodies which are administered in the days before surgery and which bind to the target lesion. The radiotracer is detected intraoperatively using a hand-held gamma detecting probe. This identifies the extent of the tumour, involvement of lymph nodes or other organs and may allow a more complete surgical clearance of the tumour. This article provides a basic understanding of the RIGS (radioimmunoguided surgery) technique, the monoclonal antibodies which are used and outlines the advantages and limitations of this technique.
Insights
Radioimmunoguided surgery (RIGS) uses radiolabeled antibodies to detect tumors missed by standard imaging. This technique helps surgeons identify cancer extent and improve tumor removal during surgery.
Area of Science:
- Oncology
- Surgical Oncology
- Nuclear Medicine
Background:
- Conventional imaging techniques may not adequately visualize the full extent of epithelial neoplasms.
- Accurate delineation of primary, recurrent, and metastatic disease is crucial for effective cancer treatment.
Purpose of the Study:
- To provide a basic understanding of the radioimmunoguided surgery (RIGS) technique.
- To outline the monoclonal antibodies used in RIGS.
- To discuss the advantages and limitations of RIGS.
Main Methods:
- RIGS involves administering radiolabeled, tumor-associated monoclonal antibodies days before surgery.
- These antibodies bind to the target lesion, allowing for intraoperative detection.
- A hand-held gamma detecting probe is used to identify the radiotracer within the patient.
Main Results:
- RIGS can delineate the extent of epithelial neoplasms, including primary and recurrent tumors.
- The technique aids in identifying local, regional, and distant spread, including lymph node involvement.
- Intraoperative detection may lead to more complete surgical clearance of the tumor.
Conclusions:
- Radioimmunoguided surgery is a valuable technique for visualizing and surgically addressing epithelial neoplasms.
- It offers improved tumor detection beyond conventional imaging methods.
- Understanding the advantages and limitations is key for its optimal application in surgical oncology.