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[Extranodal non-Hodgkin's lymphomas. Review and our experience]
C Zanon1, I Chiappino, M P Capozzi
1Cattedra di Metodologia Clinica Chirurgica, Università degli Studi, Torino.
Minerva Chirurgica
|May 1, 1996
Summary
Extranodal lymphomas, often diffuse histiocytic type, are increasing. Surgical intervention is crucial for diagnosis and therapy, with combined-modality treatment offering better outcomes for advanced cases.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Context:
- Extranodal lymphomas are increasingly diagnosed, linked to rising Human Immunodeficiency Virus (HIV) infection rates and global migration patterns.
- The study examines 12 cases of extranodal lymphoma across various sites, including the gastrointestinal tract, spleen, and breast.
- A shift towards diffuse histiocytic lymphoma is noted as the predominant pathological feature.
Purpose:
- To report clinical experience with extranodal lymphoma cases.
- To highlight the diagnostic and therapeutic importance of surgery in extranodal lymphoma.
- To evaluate treatment modalities and prognostic factors for extranodal lymphomas.
Summary:
- The authors present findings from 12 extranodal lymphoma cases, emphasizing the increasing incidence.
- Surgery plays a vital role in both diagnosis and treatment of extranodal lymphomas.
- Diffuse histiocytic lymphoma is the most common type, and prognosis for gastrointestinal lymphomas surpasses that of adenocarcinomas.
- Combined-modality therapy shows promise over local treatment for patients with unfavorable disease characteristics.
- The Ann Arbor staging system is standard, though the TNM system aids survival prediction in surgically treated patients.
Impact:
- Informs clinical practice regarding the surgical management of extranodal lymphomas.
- Contributes to understanding the changing epidemiology and pathology of extranodal lymphomas.
- Suggests improved therapeutic strategies, including combined-modality approaches, for better patient outcomes.