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Experimental immunization of hamsters with an EDTA extract of Leptospira interrogans, serovar icterohaemorrhagiae
L T de Queiroz-Leite1, M Resende, N Ramos-Vieira M das
1Departamento de Microbiologia, Universidade Federal de Minas Gerais, Brazil.
Revista Latinoamericana De Microbiologia
|January 1, 1996
Abstract:
The EDTA extract was prepared from the Leptospira interrogans serovar icterohaemorrhagiae. When inoculated subcutaneously in hamsters it conferred protection from challenge with virulent leptospires with a low dose (10 micrograms/ml) and low agglutinating antibody (40). The protection of animals obtained by the EDTA extract opens up the perspective of its use as a component of a vaccine for the control of leptospirosis.