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Related Experiment Videos

Colon perforation after lung transplantation

T M Beaver1, D A Fullerton, M R Zamora

  • 1Division of General and Cardiothoracic Surgery, University of Colorado Health Sciences Center, Denver 80262, USA.

The Annals of Thoracic Surgery
|September 1, 1996
PubMed
Summary

Lung transplant recipients have an increased risk of spontaneous colon perforation, often due to diverticulitis linked to steroid use. Early intervention and conservative surgery are crucial for better outcomes in these patients.

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Area of Science:

  • Gastroenterology
  • Transplant Surgery
  • Pulmonology

Background:

  • Colon perforation is a known complication following solid organ transplantation.
  • The University of Colorado's lung transplant program has performed 60 isolated lung transplantations.
  • Four patients in this cohort experienced spontaneous colonic perforation.

Observation:

  • An elevated incidence of colon perforation was observed in lung transplant recipients.
  • Diverticulitis emerged as the primary cause of colon perforation.
  • A correlation between steroid use and colon perforation was identified.

Findings:

  • Two patient deaths occurred in those on high-dose steroids, complicated by invasive Aspergillus infections.
  • Pre-transplant gastrointestinal screening is recommended.

Related Experiment Videos

  • Steroid-sparing immunosuppressive strategies are advised.

    • Implications:

    • Lung transplant patients with abdominal symptoms necessitate thorough investigation.
    • Surgeons should maintain a low threshold for exploratory laparotomy.
    • Conservative surgical approaches, including resection and end-colostomy, are vital for favorable outcomes.