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Chronic dermatophytosis caused by Trichophyton rubrum
1Dermatology Department, Mt. Sinai Medical Center, Greater Miami Skin & Laser Center, FL 33140, USA.
Journal of the American Academy of Dermatology
|September 1, 1996
Summary
Genetic predisposition to Trichophyton rubrum infections, a common cause of fungal nail disease, is inherited in an autosomal dominant pattern. This finding links nail infections to prior sole infections, impacting treatment and prevention strategies.
Area of Science:
- Dermatology
- Medical Mycology
- Genetics
Background:
- Trichophyton rubrum is a primary cause of fungal nail infections (onychomycosis) and athlete's foot (tinea pedis).
- The clinical relationship between T. rubrum onychomycosis and tinea pedis requires further elucidation.
- Understanding the host-pathogen interaction is crucial for effective management.
Purpose of the Study:
- To investigate the genetic predisposition to Trichophyton rubrum infections.
- To determine the relationship between distal subungual onychomycosis and tinea pedis caused by T. rubrum.
- To explore the clinical implications for diagnosis, treatment, and prevention.
Main Methods:
- The study posits a genetic basis for susceptibility to T. rubrum.
- It hypothesizes an autosomal dominant inheritance pattern for these infections.
- The research links onychomycosis to pre-existing tinea pedis of the soles.
Main Results:
- Patients exhibit a genetic predisposition to T. rubrum infections.
- This predisposition follows an autosomal dominant inheritance pattern.
- Distal subungual onychomycosis caused by T. rubrum is invariably preceded by T. rubrum tinea pedis.
Conclusions:
- A genetic susceptibility to T. rubrum infections, inherited dominantly, is proposed.
- The presence of T. rubrum onychomycosis suggests a history of T. rubrum tinea pedis.
- These findings have significant implications for clinical diagnosis, treatment, and preventing reinfection.