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Synthesis and inhibitory activities of isochromophilone analogues against gp120-CD4 binding
X L Sun1, H Takayanagi, K Matsuzaki
1School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
The Journal of Antibiotics
|July 1, 1996
Abstract:
Several isochromophilone analogues were synthesized from sclerotiorin (1) by Wittig reactions and aldol condensation reaction. The structures of the products were elucidated from MS, elemental analysis, 1H NMR and 13C NMR spectra, and their inhibitory activities against gp120-CD4 binding were determined.