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Identification of a 60-kD antigen associated with malignant growth of human breast tissue
A Chatterjee1, N Biswas, S K Choudhuri
1Department of Biochemistry, Chittaranjan National Cancer Institute, Calcutta, India.
Oncology
|September 1, 1996
Abstract:
Antisera against a novel 60-kD antigen (P60) were developed using immunomasking strategy which shows malignant growth-related expression in human breast cancer tissue. Cell adhesion assay in the presence of P60 antibody clearly indicates a role for P60 directly or indirectly in adhesion of tumor cells to extracellular matrix protein vitronectin. These results indicate that P60 could be a potential marker to distinguish benign from malignant growth of human breast tissue, and that P60 could be an integrin or a non-integrin receptor, or a receptor-related protein to vitronectin.