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Phage specific for Vibrio cholerae O139 Bengal

M J Albert1, N A Bhuiyan, A Rahman

  • 1International Centre for Diarrhoeal Disease Research, Bangladesh, Bangladesh. albert%cholera@external.ait.ac.th

Journal of Clinical Microbiology
|July 1, 1996
PubMed
Summary

A novel phage was isolated from Vibrio cholerae O139 Bengal-infected patients. This phage specifically targets and lyses encapsulated V. cholerae O139, aiding in diagnosis and variant differentiation.

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Area of Science:

  • Microbiology
  • Virology
  • Infectious Diseases

Background:

  • Vibrio cholerae O139 Bengal causes cholera outbreaks.
  • Accurate diagnosis and strain differentiation are crucial for disease control.

Purpose of the Study:

  • To isolate and characterize a phage targeting Vibrio cholerae O139.
  • To evaluate the phage's utility in diagnosing V. cholerae O139 infections and identifying capsule-deficient variants.

Main Methods:

  • Isolation of bacteriophage from stool samples of infected patients.
  • Testing phage's lytic activity against various Vibrio cholerae strains.
  • Assessing phage for diagnostic and differentiation capabilities.

Main Results:

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  • A specific phage was isolated that lysed only capsulated Vibrio cholerae O139 strains.
  • The phage demonstrated high specificity for the target bacteria.

    • Conclusions:

    • The isolated phage is a valuable tool for the confirmatory diagnosis of Vibrio cholerae O139 infection.
    • This phage enables differentiation between encapsulated and non-encapsulated V. cholerae O139 variants.