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HTLV-1 polymyositis
C J Caldwell1, W Y Barrett, J Breuer
1Department of Morbid Anatomy, London Hospital Medical College, U.K.
Neuromuscular Disorders : NMD
|May 1, 1996
Abstract:
The case is described of an HTLV-1 seropositive Jamaican woman who presented with signs and symptoms of polymyositis and myelopathy. A muscle biopsy showed features of myositis with a mononuclear inflammatory infiltrate, variation in fibre size and evidence of regeneration. Immunocytochemistry showed the mononuclear cells were composed of macrophages and T-lymphocytes suggesting a cell-mediated response. Multiplex PCR demonstrated the presence of the HTLV-1 tax gene within the muscle.