Related Experiment Video
Updated: Jul 28, 2026

17:28
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
Neurotoxicity of mercury--indicators and effects of low-level exposure: overview
Neurotoxicology
|January 1, 1996
Abstract:
The theme of the Twelfth International Neurotoxicology Conference was Neurotoxicity of Mercury: Indicators and Effects of Low-Level Exposure. Papers related to the topic appear in NeuroToxicology 16(4):1995 and 17(1):1996 (this issue). This overview provides the reader with a guide by discussing the papers under the topics of human exposure, human health effects, risk assessment, mechanism of action, and primate models.
Related Concept Videos
Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...

